The presence of TSC2 mutations, in addition to TSC1 mutations, underlines the involvement of mTOR signaling in UC.
This study provides evidence that rescued neurons possess a functional dopamine transporter and underlines the involvement of the extracellular signal-regulated kinase 1/2 signaling pathway in these processes.
A central composite experimental design was used to underline the involvement of the various biological, chemical, and physical factors influencing the fermentative biohydrogen production process.
In sporadic CRC, diffuse TOPK expression was associated with the presence of KRAS or BRAF mutation, underlining the involvement of TOPK in ERK/MAPK signalling.
This finding apparently underlines the involvement of PmrA: G54E and PmrC: R109H substitutions in the development of colistin resistance in A. baumannii isolates of ST101.
Moreover, these findings may underline the involvement of exosomes in the regulation of immune responses - either induction of tolerance or immune defense [ 36- 38].
These results underline the involvement of NF-κB and indicate the supportive action of NF-κB on PM-mediated transcriptional activation of pro-inflammatory genes.
We also confirmed that the ∆ESAT-6 strain was unable to cause clustering of monocytes at the sites of infection, further underlining the involvement of this virulence mechanism in the formation of early granulomas (Fig. 3A).
Stimulation of P2X7 receptors is implicated in microglia response to inflammation, release of proinflammatory cytokines, like IL-1 β, and proliferation [ 58], underlining the involvement of this receptor subtype in inflammatory diseases and pain.
This hypothesis is substantiated by data from The Chisari Lab, underlining the involvement of the autophagy machinery in the translation and/or delivery of incoming viral RNA to the translation apparatus, while it becomes dispensable for HCV RNA progeny once replication is established [ 52].
