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These results suggest that PDE4 inhibitors are effective in inhibiting the pro-MMP-2 and pro-MMP-1 secretion induced by TNF-α and might underline a potential therapeutic benefit of selective PDE4 inhibitors in lung diseases associated with abnormal tissue remodelling.
These results underline a potential virus transmission from animal to animal via virus-containing droplets as it has been described in naturally occurring smallpox infection in man.
Our findings further underline a potential involvement of VEGF-A, VEGR1 and VEGFR2 in events occurring at the invasive tumour front and highlight a possible prognostic role of VEGFR1 expression in mismatch repair-proficient colorectal cancers.
Moreover, our data underline a potential additive effect of curcumin with gemcitabine thus providing an efficient therapeutic option for antilung cancer therapy.
Other activities, e.g. interaction with various receptors that modulate cytokine release and intracellular signalling pathways, activation of transcription factors and production of matrix metalloproteinases, underline a potential role of A-SAA in atherogenesis, coronary syndrome, and tumor pathogenesis [8 10].
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That's an understandable business model, but it underlines a potential contradiction in how the game is positioned: Casual, younger players are the bulk of the market, but many have probably never heard of Mr. Garriott.
The fact that CORT and diverse NK1 receptor antagonists are currently in various stages of clinical trials concerned with the treatment of anxiety disorders [28], [31], [77], [78] underlines a potential translational value to the present results in HAB mice.
Although the extent of similarity between HIV and human proteins is relatively limited, a variety of segments are shared between HIV and host proteins, particularly proteins involved in host immunity, underlining a potential role of HIV-1's similarity to host in the interference with effectors of the immune system.
Interestingly, this upregulation was particularly evident among therapy responders, again underlining a potential relationship between endocrine treatment, SRCs, HER-2 and treatment response that should be further explored.
The localisation to important mitotic structures and the overlap with the localisation pattern of Ska1 (Hanisch et al, 2006) underlines a potential interaction of these proteins.
The results from these analyses underlined a potential involvement of GLI1 as a transcriptional regulator important for breast cancer development as increased levels of GLI1 expression were shown in four out of five analysed samples.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com