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Potential inhibitors would bind to two metal ions in the active site of HIV IN to prevent human DNA from undergoing the integration reaction.
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The GR is also supposed to undergo the integration process, but in January 2007, only one battalion had been announced as been integrated.
We excluded from the analysis any clones that expressed the reporter shortly after transduction on the basis that, in these clones, the construct may have undergone rearrangement during the integration event or multiple copies of the construct may have integrated as a tandem array.
It is currently undergoing integration with the STAR experiment in preparation for data taking that starts in mid-2000.
In the 'interface-sliding' pathway, the TMD enters the cytoplasm through the gap between the translocon and ribosome, prior to undergoing membrane integration.
In the 'interface-sliding' pathway, the TMD enters the cytoplasm through the gap between the translocon and ribosome, prior to undergoing membrane integration; a trajectory thus exhibits this pathway if a TMD visits IS4 on the way to membrane integration.
The technique can also be applied in gene therapy trials to study modifications at ends of transfected DNA, which the DNA undergoes before integration into the genome.
Financial capital of the 12 members will undergo deep integration under the TPP framework and will be mutually pegged.
Tilting reactions are abnormal in PD, suggesting that the labyrinthine postural reactions undergo central integration in the basal ganglia [ 3].
Importantly, we have defined a specific population of cells that undergoes robust integration into the host DG after transplantation.
ASEAN, a region currently undergoing an ambitious integration initiative proposed a unified regional banking system thru the Qualified ASEAN Banks.
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