It can be noted that a given P-lacZ insertion P-10399) expressed in various tissues, undergoes repression in the nurse cells but not in the somatic cells nor in the testis.
Among these, the expression of 10 members from the LysR, MarR, TetR and AsnC family of transcription factors undergo repression as the cells undergo cyst development (RC1_0825, RC1_1178, RC1_1377, RC1_1428, RC1_3526, RC1_3708, RC1_0145, RC1_0443, RC1_3536, RC1_3691).
Baek et al. [39], have shown that genes undergoing microRNA repression by more than a third also display detectable mRNA destabilization, and that highly repressed targets were silenced primarily at the mRNA level.
For example BC69, located on the second chromosome, almost never undergoes complete repression, whereas BQ16 or P-Co1 can show nearly complete repression covering all stages of oogenesis.
One hopes that this long suffering people, Europe's last vestiges of the ancient Mongols, will not undergo further repression at the hands of the Moscow-based state that brought them close to extinction in the Tsarist and the Soviet eras.
Interestingly, H3K4me3 is retained among a set of genes that undergo transcriptional repression, or 'silencing' during the process of malignant transformation.
Perhaps most importantly, this approach aligns with the goals of a biologist considering the top-ranked predictions in an attempt to focus on those most likely to undergo substantial repression.
Indeed, AQP6 may be expressed as an early gene in a developmental stage of the MNC that undergoes gene repression: this stage corresponds to the differentiation process of this cell lineage culminating in the phenotype of the fully functional mature zymogenic and parietal cells.
BDNF is a secreted neurotrophin, which undergoes transcriptional repression in certain HD models, and there are indications that over-expression of BDNF can ameliorate the HD phenotype [ 8]. Cell death in the striatum and cortex are hallmarks of HD; hence, this shared observation is significant, as it recapitulates in vitro what is seen in vivo.
