The HRD real-time wind analysis system is currently undergoing evaluation in the operational forecasting environment of the National Hurricane Center.
Ceftobiprole is currently undergoing evaluation by the US FDA for the treatment of complicated skin and skin structure infections, with a decision pending further evaluation of study site monitoring.
ITF2357 has been tested in Phase II clinical trial for Hodgkin's lymphoma, chronic myeloproliferative diseases and juvenile idiopathic arthritis, and is currently undergoing evaluation for long-term study on chronic myeloproliferative neoplasm (ClinicalTrials.gov Identifier: NCT01761968).
Multiple direct anti-factor Xa agents are currently undergoing evaluation in phase I, II, and III trials.
Among poxviruses, MVA vectors (the attenuated poxvirus strain modified vaccinia virus Ankara) have already generated very promising results in in vitro studies [17], [20] and in simian model of HIV infection [21], [22] and, on this basis, they are also currently undergoing evaluation in human trials [23] [26].
In addition, other novel approaches are currently undergoing evaluation.
MEDI-551 is currently undergoing evaluation in clinical trials (Table 1).
Of note, BSI-201 is currently undergoing evaluation in a multicentre, open-label, randomized phase II trial in 120 patients with triple-negative MBC.
In this perspective, several new drugs are currently undergoing evaluation, and many appear very promising on the basis of reported initial results [ 2, 3].
Because TUDCA and PBA are currently undergoing evaluation (http://clinicaltrials.gov identifiers: NCT00771901, NCT01877551) on insulin-resistant subjects (a population typically also affected by increased body adiposity), our results caution for evaluation of cancer risk in these patients.
Further, several HDAC inhibitors are currently undergoing evaluation in clinical trials and encouraging antineoplastic effects at well-tolerated doses have been observed in both haematological and solid cancers [ 14, 15].
