Your English writing platform
Discover LudwigExact(2)
China is still undergoing class struggle, Mr. FlorCruz recalls being told by his minders.
AID-induced DSBs and Nbs1/gamma-H2AX focinin the switch regions of the IgH locus are observed in the G1 phase of cells undergoing class switch recombination (Petersen et al. 2001; Schrader et al. 2007), similarly to point mutations in the V region (Faili et al. 2002).
Similar(58)
To produce a functionally diverse antibody repertoire B lymphocytes undergo class switch recombination.
Within the germinal center (GC), antigen activated B cells undergo class switch recombination (CSR) and somatic hypermutation (SHM).
The GC is the site where antigen activated naïve B cells migrate, proliferate and undergo class switch recombination, antibody gene diversification and affinity maturation [10].
The results demonstrated that human B cells developed by DRAG were functional as they secreted all human immunoglobulin classes, whereas those from control mice were impaired in their ability to undergo class switching and secreted only IgM.
It is known that in mice, Th1 biased T helper cell responses favor the production of antigen specific IgG2a and IgG3 while Th2 responses prompt B cells to undergo class switch recombination towards IgG1 and IgE [24], [25], [27].
Since the CD27−IgD− cell subset, which appears to be enhanced in the peripheral blood of patients with SLE [36], [37] might include B cells which may have undergone class switching simply by exposure to TLR-ligands or cytokines such as IL-10 or IL-21 or BAFF [38], [39], [40], [41], this subset was considered to be heterogeneous.
B1 B cells have also been found to undergo class switch recombination from IgM to IgA.
Naïve B cells undergo class switching leading to the development of memory B cells and plasma cells that produce IgE.
Thus the class-switched transcripts are derived from IgM+ cells that apparently have already undergone class switching but have yet to turn off IgM surface protein expression.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com