To determine whether Bax undergoes conformational changes in OPCs during excitotoxicity, we determined whether conformation-specific Bax was present in OPCs prior to apoptotic death.
SERCA undergoes conformational changes as it harnesses the chemical energy of ATP for active transport.
Reiser, J. B. et al. A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.
As for formulation pH, rhBMP-2 undergoes conformational changes and aggregates when shifting from acidic to neutral pH conditions.
It should be noted that the activated form of Vn undergoes conformational changes and partial unfolding, and thereby exposes potential binding sites10, which is likely a reason why the activated form is predominantly targeted by bacteria.
The H-state Hs-cHisRS undergoes conformational changes in active site residues and several conserved motif of HisRS, compared to F-state structures.
Here we determined the architecture of the yeast Rvb1/2 dodecamer using cryoelectron microscopy and identify that the substrate-binding insertion domain undergoes conformational changes in response to nucleotide state.
Since GBP1 is a large GTPase which undergoes conformational changes in a nucleotide-dependent manner, we investigated the effect of GTP/GDP binding on GBP1 PIM1 interaction by using computational and biological studies.
It was the first to provide structural information for the dynamic docking of the PGH2 mimic of the TXAS in solution, and to imply that PGH2 undergoes conformational changes when bound to different COX-downstream synthases, which may play important roles in the isomerization of PGH2 to different prostanoids.
Post DNA binding, cGAS forms dimerization and undergoes conformational changes that render the spine region twisted, promoting synthesis of cGAMP.
These data indicate that VR1 undergoes conformational changes upon capsaicin binding that it does not undergo in response to activation by protons or thermal stimuli.
