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Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
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At this point, the focus shifts towards individuals undergoing combination and multiple therapies.
For example, the main drug targets in HIV, reverse transcriptase and protease, undergo mutation and selection for drug resistant variants in patients undergoing combination drug therapy [8].
Five patients dropped out of the study before completion of 6 months of atorvastatin treatment; two of them underwent combination therapy with IFN-β and experienced a relapse.
In addition, there was minimal toxicity in patients with unfavorable CaP who underwent combination therapy.
The median survival time of patients undergoing combination therapy was significantly longer than that of patients receiving TACE alone (19 months vs. 11 months, P = 0.01).
In order to ascertain the incidence and prognosis of cisplatin-induced neurotoxicity in testis cancer patients undergoing combination chemotherapy, 29 patients with metastatic disease were studied prospectively.
The first evidence for a role of NRG-1/ErbB signaling in adult heart function comes from clinical studies in patients with metastatic mammary carcinoma, undergoing combination therapy.
In patients undergoing combination of external radiation and brachytherapy the use of IMRT is associated with decreased incidence of grade II or higher bowel toxicity.
Whereas HCV treatment is currently not offered to children <2 years of age, 55%-93% of children in the 2-17 agroupoundergoinging combination treatment achieve sustained viral response.
All patients underwent combination chemotherapy with oxaliplatin or irinotecan plus 5-fluorouracil/leucovorin or a prodrug of 5-fluorouracil as first-line chemotherapy.
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