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Patients must undergo upfront systemic chemotherapy for at least 4 courses before inclusion.
Eligible patients will undergo upfront PIK3CA genotyping as the trial will essentially have two identical cohorts in order to ensure that the PIK3CA mutant population is adequately powered.
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In 102 CRLM patients with 8 or more tumors who underwent upfront hepatectomy without chemotherapy, the 5-year OS rate of 33%% was relatively good, but the 5-year RFS rate was only 1.7%% [4].
A large number of liver metastases have the greatest impact on disease-free survival (DFS) and overall survival (OS) for patients with colorectal liver metastases (CRLM) who underwent upfront hepatic resection [1].
To assess outcomes of women with cervical cancer undergoing upfront radical hysterectomy (RH) via a minimally invasive surgery (MIS) or a traditional laparotomy (XL) approach at 2 large US academic institutions to determine whether the mode of surgery affects patient outcomes.
6 patients underwent upfront surgery (Group A) while 18 patients received 4 weeks of chemotherapy (Group B).
These findings illustrate the significance of achieving and confirming R0 resection in patients undergoing upfront surgical resection for PaCa.
Efficacy of neoadjuvant CRT in improving 3-year survival probability from 30% in the control arm undergoing upfront surgery without neoadjuvant CRT to 42% (relative increase of 40%) in the study arm undergoing CRT.
We evaluated the clinical significance of prognostic factors including the International Staging System (ISS) and modified European Group for Blood and Marrow Transplantation response criteria in 1650 Japanese patients with multiple myeloma (MM) who underwent upfront single autologous stem cell transplantation (ASCT).
The underlying hypothesis of this randomized, two-armed, open-label, multicenter, phase III trial is that neoadjuvant CRT increases the three-year overall survival by 12% compared to patients undergoing upfront surgery for resectable pancreatic cancer.
These results indicate that the response rate and OS were significantly improved, and the ISS could not clearly stratify the prognoses of Japanese patients with MM who underwent upfront single ASCT during the novel agent era.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com