Moreover, unlike the methylated sRNAs associated with AGO2, the AGO1-bound non-methylated sRNAs undergo target-guided tailoring and trimming, which contributes to the efficiency of sRNAs with limited complementarity to the target [75].
The large T antigen is known to undergo targeted proteasomal degradation as part of the DNA damage response [36].
Our findings are also consistent with studies carried out with primary cultures of human progenitors [40], [48], [49] and provide the initial evidence that neural progenitors that are continuously produced by a renewable source of hNSCs can undergo targeted migration to different areas in the adult brain affected by a global ischemic lesion.
Adult relatives of mutation carriers can then undergo targeted genetic testing.
Mitochondria clearly undergo targeted destruction and require robust quality-control mechanisms, which are very active areas of investigation.
In our institution all such patients undergo targeted ultrasound of the symptomatic area within the breast; and mammography if aged 40 years or over.
Following endocytosis, receptors may undergo recycling back to the plasma membrane, which is thought to underlie re-sensitization, or may undergo targeting to the degradation pathways, a key process in receptor down-regulation.
The aims of this study were to establish whether, and the extent to which, the phenomenon of risk escalation occurs in men who undergo targeted biopsy, by means of a computer simulation.
Previously, we have shown that nanocapsules fabricated from star-shaped bis-aminated PGOHMA (BA-PGOHMA) and poly acrylic acid) (PAA) using the layer-by-layer (LbL) self-assembly method are pH-responsive and undergo targeted release of their cargo, indicating they are promising candidates as gate components on MSNs for drug delivery and gene therapy.
Each trial reported the percentage of patients in each arm who underwent target lesion revascularization (TLR) after stent implantation.
Stone et al found that about 1.4% of patients undergoing target lesion revascularisation developed a myocardial infarction associated with the procedure.
