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As necroptosis undergo pathway independent of apoptosis, all the barriers set up in cancer cells to avoid apoptosis are no longer problems for necroptosis.
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Similarly, SL interactions predicted from 'static' pathway maps do not reflect the actual scenario in cancer cells; these cells undergo significant pathway rewiring to enhance their viability [ 39, 40].
We found that GBM cells, when acutely exposed to high oxygen tension, undergo Akt/mTOR pathway activation and that BMP2 acts in an analogous way.
A declining trend was observed for both the microspheres incorporated cryogel as shown in Figure 5. Glucose is essential for the cells to undergo aerobic pathway and is well established by Korinkova and Lodin with their experiments [ 29].
The components of the Par complex are evolutionarily highly conserved and mutations in genes encoding Par complex proteins are associated with hyperproliferation, tumour formation and increased metastasis in humans [ 13] Basally localized proteins are segregated into the GMC (ganglion mother cell) during neuroblast asymmetric division and are important for GMCs to undergo differentiation pathway.
It is suggested that the magic-sized nanoclusters can undergo two pathways after the formation.
Mechanistic investigations indicate that the donor-acceptor systems undergo different pathways in presence of tertiary and the secondary amine.
FA is known to undergo two pathways of decomposition, to give either H2 or carbon monoxide (Scheme 1).
Activation of caspases as diseased cells undergo apoptosis pathways may trigger cleavage, as is the case with endogenous Ataxin-3 protein in Cos-7 cells (9).
Monocytes from circulation that enter the kidney in response to inflammation undergo separate pathways of differentiation into classically activated M1 macrophages or the alternative M2 phenotype.
To achieve an optimum state for survival, a cell may undergo various pathways in the ER, such as ones that regulate protein folding, posttranslational modifications, lipid and steroid synthesis, gene expression, cellular metabolism and calcium signaling.
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