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It is becoming increasingly clear that the fundamental capacity to undergo conformational change in response to ligand binding is intrinsic to proteins.
The aptamer complexes were designed as molecular switches to undergo conformational change and release fluorescent label upon interaction with the flow of the analyte, causing fluorescence decrease.
Alternatively, additional PrP molecules may be "induced" to undergo conformational change, which is to say the presence of a nucleation site increases the probability of an alpha to beta transition much as an enzyme might speed the rate of a reaction.
Our findings suggested that depending on distinct partners and post-translational modifications, Axin may undergo conformational change during its differential assemblies with "destruction complex" or "Wnt-LRP5/6 signalosome".
Exon analysis shows that the two N-terminal glutamic acid-rich sequences which are predicted to undergo conformational change upon binding of calcium, as well as the C-terminal EF-hand Ca2+-binding domain are each encoded by a single exon.
MENT, a protease inhibitor of the serpin superfamily, is able to undergo conformational change in order to effect enzyme inhibition.
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Enzymes undergo conformational changes during the catalytic process and conformation sensitive antibodies offer a means of monitoring these changes.
Soluble Aβ initially adopts an extended conformation but at high concentrations, soluble Aβ will undergo conformational changes and form oligomers, protofibrils, and fibrils.
So they undergo conformational changes.
Protein molecules often undergo conformational changes.
As suggested by our SMFS experiments (Fig. 3) during gating, these residues are expected to undergo conformational changes.
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