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The deviation of preclinical dosimetry results from clinical study results suggests a systematic underestimation of the effective dose in humans below 50%% when determined using animal models.
The underestimation of absorbed dose in the mouse gallbladder (20 times lower) and liver (3 times lower) relative to the human PET studies may have been responsible for the underestimation of the effective dose.
As some exposure to x-rays when not wearing an apron is possible, applying the apron protection factor to the full Hp(10)x-rays could result in an underestimation of the effective dose.
It is however possible that a smaller Ne in the first period was in part due to an underestimation of the effective size of populations that have just been brought into the lab from the wild, having thus suffered a recent bottleneck.
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Besides that, we have shown that ignoring the mass-transfer limitations leads to a noticeable underestimation of both the effective diffusion coefficient and the specific sorption capacity of the clay.
That could result in an underestimation of the effect.
Attrition bias may have led to underestimation of the effect.
This may result in an underestimation of the actual effect.
This will have resulted in underestimation of the intervention effect.
In addition, the 3D numerical predictions agree more with the experimental results, since the heat conduction in the third direction is omitted in 2D simulation, leading to the underestimation of effective thermal conductivities prediction in the same boundary conditions.
This disparity will result in underestimation of the treatment's cost effectiveness and will particularly disadvantage effective but costly treatments.
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CEO of Professional Science Editing for Scientists @ prosciediting.com