Overall, these features suggest that both chromosomal coverage at the ends and segregation distortion may have contributed in part to the underestimation of NM length and/or overestimation of FA length for several linkage groups.
Coleman added that one of the problems with assessments has been an underestimation of the length of time it will take for each one to take place.
This discussion includes an examination of the problems and their causes: lack of realism, the underestimation of the length and cost of the delays, and others.
Another reason for the difference may be the difficulty in the determination of the FMCG T wave, its low amplitude waveform shape leading to underestimation of its length.
Underestimation of branch length was correlated with underestimation of substitution model parameters, calculated as kappa (the transition/transversion ratio scaled by base frequencies) (Pearson's correlation coefficient = 0.343; P < 0.0001).
Knowing that using peak weeks as indicator for activity would lead to underestimation of the length of the epidemic, because periods of high activity at the beginning and the end were not taken into account, 4 weeks were added: 2 weeks before the earliest peak and 2 weeks after the last peak.
Underestimation of branch lengths can result from uncounted multiple substitutions at some sites [ 23, 24].
