The root problem is a dramatic underestimation of the complexity of interactions between implant design, materials, and the biological system.
Both of these views have not only resulted in a general underestimation of the complexity of the living world, but also have led to grossly inaccurate paleoecologic reconstructions, have made it seem that neoecology was running out of steam, and – I think most seriously – have limited the growth and expansion of evolutionary theory.
Furthermore, in a mixture of heterogeneous sequences, certain bands may overlap, resulting in underestimation of viral complexity.
Initial expectations of rapid gene identification have been based on an underestimation of the complexity of the disease, even if it is bound to be less extensive than in the human situation.
"This would lead to an underestimation of the genetic complexity affecting aggressive behavior," MacKay says.
This may indicate an initial underestimation of the relative complexity of behavior change support.
An apparent underestimation of the full complexity of CCRs is well demonstrated in patient 1, in whom a complex karyotype was identified, including an inverted insertion of the MDLS region into the middle SMS-REP/LCR17pB block, two microdeletions (terminal and interstitial in 17p12) and a microduplication involving both SMS and CMT1A chromosome regions.
None of the existing rules is ideal; weaknesses include low sensitivity or specificity, excessive complexity, underestimation of severity in younger patients, and poor prediction of ICU admission.
The recent literature debate about cancer biomarkers has focused attention to several crucial aspects and caveats: a) complexity and underestimation of the problem, b) missing data on cancer biology knowledge, c) funding limitations, d) inappropriate clinical setting, e) unpromising discovery and scarce/neglected validation, f) pre-analytical and methodological shortcomings, etc. [ 18- 20].
The Deputy Minister perhaps underestimates the Colonel, underestimation of one's adversary being a fatal weakness of many ambitious men.
They're suspicious of complexity.
