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There was no difference between the discomfort caused by "up" and "down" shocks of the same vibration dose value, but the Wb frequency weighting slightly underestimated sensitivity to low-frequency shocks.
However, inclusion of women over age 50 years could have led to an underestimated sensitivity for VIA.
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This outcome suggests that the SSO model may underestimate sensitivity and acuity for young, well-corrected observers.
This will underestimate sensitivity and specificity.
Conversely, a perfect clinical gold standard does not exist and therefore clinical gold standards are likely to underestimate sensitivity while overestimating specificity.
The outcome of utilizing this weighting strategy is that their reported average sensitivity underestimated observed sensitivity in the six studies with full criterion information by 14%, and underestimated observed specificity by 12%.
Well, it means that studies based on observed warming (such as the recent low climate sensitivity studies) have underestimated the sensitivity because they did not account for the greater response to aerosol forcing.
As discussed above, we may have underestimated the sensitivity of the Dräger Alco-Check because of a suspected protocol violation.
Because these were all shown by our Sanger analysis to be HapMap Project genotyping errors, this would have underestimated both sensitivity and specificity.
Therefore the cost effectiveness of some of the described risk groups might have been underestimated, although sensitivity analyses showed that our conclusions remained valid when we increased the incidence.
However, we might have underestimated the sensitivity of the guaiac-based test for detecting upper gastrointestinal lesions as occult blood was more likely intermittent and unevenly distributed in the stool, requiring multiple samples.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com