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Here, we derive an adjusting factor for the required information size under any random-effects model meta-analysis.
Pack into the required serving sizes for your specific needs.
So, for a trial with a fixed number of equal sized clusters (k) the required sample size per arm for a trial with pre-specified power 1 - β, to detect a difference of d, is n C, such that: (13) where n I is the sample size required under individual randomisation.
n = the required sample size.
The required information size was 4894.
Under the optimality criterion of Simon, the required maximum sample size for each dose was 45, with 17 in the first stage.
The required minimal group size was N=50.
The required minimum sample size was 350.
The required minimum sample size was guaranteed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com