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The association under the recessive model still remained significant.
Interleukin 6 (IL6):resulted5 resulted in an 2.16-fold increased risk (95% CI 1.18 3.94) under the recessive model.
Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model).
As shown in Table 4, in AAs, the haplotypes significant under the recessive model were negatively associated with FTND, SQ, and HSI, whilst the two significant haplotypes under the dominant model were positively associated with FTND.
Interestingly, these directions were reversed in EAs; all the significant haplotypes under the recessive model were positively associated with FTND, SQ, and HSI, and the dominant haplotype was negatively associated with SQ.
We selected 1536 SNPs for the Stage 2 Golden Gate custom array, based on a number of conditions: 1433 were significant under the additive model, either at p<10−3 for one of the four primary phenotypes, or at p<10−5 for the two metabolic syndrome phenotype, or at p<10−5 under the recessive model for any phenotype.
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There were suggestions for associations with a fourth SNP rs1272 under the recessive models (p = 0.10) but these did not achieve nominal statistical significance.
We observed that imputation had less impact on the power of the test under the recessive models than that under the other disease models.
The chromosome 3 peak produced a higher maximum hLOD score under a recessive model (4.652) than a dominant model (3.334), whereas the maximum hLOD score for the chromosome 9 peak was higher under the dominant model (3.883) than the recessive model (2.680).
Mann-Whitney test was used for the association of Gensini scores with rs7529229 under the dominant and the recessive models.
We had 80% power to detect a hazard ratio of 1.57 under the tested recessive model of inheritance, given our sample size of 704 participants and a minor allele frequency of 17%.
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