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The practical response values under the optimized formulation were in good accordance with the predicted values.
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Under the optimized formulations, the log-transformed of CFU mL− 1 on the Staphylococcus aureus and Escherichia coli are 0.84 and 1.26 (the log-transformed of CFU mL− 1 of negative control groups on the Staphylococcus aureus and Escherichia coli are 8.21 and 8.47), respectively.
The optimized formulation was selected through numeric optimization approach.
The stability study was performed by measuring the size of the optimized formulation of magnetic micelles at the various designated time points under room temperature.
The optimized formulation was calculated and examined.
The optimized formulation was used for cell line studies.
The optimized formulation of LCDP showed a significant increase in dissolution rate compared to the drug suspension under the same conditions.
Furthermore, physicochemical characterization of the optimized formulation was performed.
The optimized formulation was characterized by DSC, FTIR, XRD and SEM analysis.
The drug entrapment efficiency of the optimized formulation was determined to be 75 ± 5%%.
The optimized formulation had significantly greater anti-inflammatory effects than the commercial formulation.
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