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Under the linear-threshold model, the influence of a single frequency component on the neural response varies with the intensity, while under the multiplicative model it does not.
In order to calculate the lifetime risk, we take the product of the relative risks across all loci (this is the overall relative risk of the individual under the multiplicative model) and multiply it by the average lifetime risk of the disease in the population.
In the present study, we asked two follow-up questions: (1) whether the observed deviations could be estimated directly from the double-mutant phenotypes under the multiplicative model; and (2) whether the prediction of specific functional links could be made at a similar accuracy without utilizing the measurements of single-mutant phenotypes.
Under the multiplicative model neither of the factors is a significant predictor.
None of the other polymorphisms was associated with breast cancer risk for BRCA2 mutation carriers under the multiplicative model.
The interaction test for body mass index and 25(OH D was statistically significant under the multiplicative model (Pinteraction < 0.01).
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The high correlation between the causal and hit SNPs then means that there is reasonable power to detect deviation from the multiplicative model, even under model distortion.
For example, take the multiplicative model of Changling.
It was found that the multiplicative model works well.
For the submultiplicative model, prediction is improved with respect to the multiplicative model while, for the supra-multiplicative model, prediction is worse.
It can be calculated numerically by fitting the multiplicative model, using logistic regression, to the theoretical genotype frequencies for cases and controls under the disease model of interest, weighted by the case-control sampling ratio.
More suggestions(15)
under the standard model
under the trichotomous model
under the nonprofit model
under the symmetric model
under the French model
under the same model
under the Soviet model
under the wholesale model
under the Periodic model
under the exponential model
under the dominant model
under the additive model
under the recessive model
under the new model
under the multiplicative null
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Justyna Jupowicz-Kozak
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