Under the dominant model, the association was not significant.
As shown in Table 4, in AAs, the haplotypes significant under the recessive model were negatively associated with FTND, SQ, and HSI, whilst the two significant haplotypes under the dominant model were positively associated with FTND.
For example, the P values of associations with SI, SQ, and SC for the haplotype ACT, formed by rs950776-rs11072768-rs7166158 under the dominant model, are, respectively, 0.001, 0.014, and 0.019 in the male sample and 0.013, 0.033, and 0.06 in the total sample.
Under the dominant model, all tests have comparable power.
Analysis under the dominant model yielded no signals across the entire genome.
Under the dominant model, the OR was 1.49 (95%CI: 1.09 2.05) among carriers of the TA/AA genotype.
Figure 3 are the results of the association under the dominant model (AC + CC versus AA) from fixed effects analysis.
Interestingly, a conflicting association was found in Caucasians under the dominant model (OR = 0.78, 95% CI = 0.62 0.99).
(i) The APOB p.E4181K polymorphism (under the dominant model) is associated with an increased risk for hypertension.
Disease allele frequency and age dependent liability classes were as above, under the dominant model [ 29, 30].
Another GWAS-discovered SNP, rs245201, showed a marginal association with schizophrenia (P = 0.052, under the dominant model).
