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Under the alternative model of later gene flow between Neandertals and modern humans, we expect Neandertals to match alleles in individuals from some parts of the world more often than the others.
We evaluated the power of MIXStrat relative to the power of MIX under the alternative model.
Under the alternative model, if the population structure among present-day Africans predates the OOA migration, we might find some African populations show a signal of Neanderthal introgression whereas others do not.
This gives an indication of how much the distribution of networks under the null model differs from the distribution under the alternative model in which node degrees are not preserved.
Confounding factors that affect most maximum likelihood phylogenetic methods include: the number of taxa, the divergence time, the proportion of sites that fall under the alternative model and the strength of signal.
To examine the sensitivity and FP rate (Fawcett, 2006) over a range of tree lengths (sum of all branches), we generated simulated data with a 16 taxa tree, 50% of sites under the alternative model (in the null case W p [0] == W p [1] == length + 2).
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Figure 7 shows that, (a) the nonparametric age and BMI effects are close to their counterparts under the alternative models and may be simplified to parametric effects; (b) In both the logistic and the linear parts of the model, the HDL effects are highly nonlinear and have a "U" shape.
In each comparison, the null model does not allow the presence of sites under positive selection, while the alternative model allows for selection.
A gene does not necessarily need a large proportion of sites under diversifying selection to fit the alternative model better.
Under the stage 1 analysis using the alternative model assumptions where post-vicariance migration (M2) was 0.0 under the soft vicariance model, estimates of Z and E2) were respectively 3.64 and 0.66 (95% credibility intervals 0.00 – 9.74 and 0.35 – 0.35).
Second, we provide a thorough discussion of some common situations in which the standard form of LM tests cannot be computed because the information matrix of the alternative model is singular under the null.
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under the polygenic model
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under the wholesale model
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under the old model
under the alternative adaptation
under the alternative method
under the alternative approach
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under the alternative rescaling
under the antiquated model
under the dominant model
under the French model
under the alternative arrangement
under the alternative vote
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com