Traditional media, under stringent control from propaganda officers, are afraid of making mistakes.
Each step of the apoptotic signalling cascade is under stringent control.
Because of its importance, the transcription level of GDF-15 is under stringent control of various regulatory pathways.
The process of proliferation and differentiation of the follicle cells is complex and under stringent control [ 37- 39].
When PA28γ is present, p53 is efficiently polyubiquitinated by low levels of MDM2 within the nucleus, and the p53 level remains under stringent control by MDM2.
Transcription of 6S RNA is not under stringent control in vitro and in vivo, when ppGpp reaches millimolar concentrations [ 7, 10].
Alternatively, these genes can be expressed from a stably integrated defective prophage, where exo, bet and gam are controlled by the strong phage promoter pL, under stringent control of the temperature-sensitive repressor, cI857[ 36] 36].
However, a recent indication that the germline DNA demethylation pattern of the DAZ gene is under stringent control (Navarro-Costa et al., unpublished results) suggests that epigenetic disturbances in AZFc may be a likely phenotype modulator.
Centrosome separation is under stringent control by mitotic kinases, such as cyclin-dependent kinase 1 (Cdk1), polo-like kinase 1 (Plk1), Aurora A and Nek2, but it remains to be shown in detail how these kinases contribute to this process.
Mitochondrial DNA copy number in cell is not under stringent control; and various internal or external factors associated with ATP demand may influence its level, such as: exercise (Lim et al, 2000), hypoxia (Hoppeler et al, 2003), and steroid hormones stimulation (Weitzel et al, 2003).
