Complementation of essential yeast genes by candidate human gene orthologs can be tested by the ability of a human cDNA to rescue lethality caused by (i) a null allele (deletion in a haploid strain), (ii) a conditional allele under restrictive conditions (e.g., temperature-sensitive strain), or (iii) downregulation by a repressible promoter (e.g., Tet system) (Kachroo et al. 2015).
It is shown that the widely-used approach of a revenue-neutral fixed feed-in tariff can yield an optimal outcome under restrictive conditions only.
Presumably, Pfister's next directorial venture will be somewhat scaled back; having earned his spurs in the Roger Corman stable, he knows how to work fast and cheap, to achieve extraordinary results under restrictive conditions, to turn adversity to his advantage.
Not long after Russ George set the regulatory alarm bells ringing, the London Convention, which regulates ocean dumping, and the Convention on Biological Diversity both passed resolutions banning iron fertilisation experiments except under restrictive conditions.
Mr. Abdel Rahman, 63, who was sentenced to life in prison plus 65 years, has been held in a federal prison in Rochester, Minn., under restrictive conditions because of fears he might pass messages to outsiders.
Others are not cancelable during the year's term of coverage, but the insurer may refuse to renew coverage for a subsequent year or may renew only at higher rates or under restrictive conditions.
Adaptive speciation in the purest sense of the word is indeed feasible under this scenario, but again under highly restrictive conditions.
He now lives under extremely restrictive conditions, tagged and isolated.
Localization in pure mutation landscapes is only possible under extremely restrictive conditions.
As a rule, large banks don't lend to the poor, while microfinance institutions do, but under very restrictive conditions.
Even under highly restrictive conditions down to one cell per well, CD95high GBM cells showed profound sphere-formation capacities.
