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Non-motor nervous dysfunction was not detectable: Increased sweating was not observed in aged Pink1−/− mice even under pharmacological provocation (Fig. S5).
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Pharmacological provocation with intravenous ajmaline administration was performed.
Pharmacological provocation test was carried out on the whole study group.
The pharmacological provocation test was positive in the man and negative in the woman.
The patient with this variant was a man with asymptomatic BS diagnosed based on pharmacological provocation.
Specific pharmacological provocation tests with class I medicine are critical in revealing concealed ECG features of BS.
Molecular tests were performed in the family members of patients with BS, even if the pharmacological provocation test was negative in these individuals.
The patients with this polymorphism (a woman and a man) were asymptomatic; pharmacological provocation test was positive in the man and negative in the woman.
The first variant contained change in nucleotides in 38589682 position (C>A) of reference sequence and was observed in 1 patient with negative result of pharmacological provocation.
To further examine heart rate modulation in vivo, we used pharmacological provocation with isoprenaline (3.0 μg/kg intraperitoneally) and carbachol (0.5 mg/kg intraperitoneally).
The 3 persons were asymptomatic 2 men with positive pharmacological provocation test and a woman related to one of the men (daughter) with a negative result.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com