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Strain replacement was faster under low oxygenation levels.
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There were no indications for significant improvements of tumour oxygenation by adaptive mechanisms under low oxygen breathing conditions for days.
As the selection of p53-defective cells has been described as a consequence of cyclic hypoxia and Wt p53 undergoes conformational change in to mutant form under low oxygen concentration, we asked if re-oxygenation at normobaric pressure could trans-activate p53 and its downstream genes in regressing of hypoxic tumor.
Because these vascular treatments can affect oxygenation of tissue, hypoxia was evaluated by staining for PHD2, an oxygen-sensing molecule that modulates hypoxia-inducible factor (HIF) response under low oxygen levels.
Moreover, as many as 25% of islets are exposed in vivo to low oxygenation [ 5], suggesting that hypoxia acts as a regulator of islet function under physiological conditions.
The genes encoding TCA cycle enzymes are down-regulated in low oxygenation [ 32].
Hypoxia, or low oxygenation, has emerged as an important factor in tumor biology and response to cancer treatment [ 1].
We speculated that this result may be due to low oxygenation of the culture in a microtiter plate.
In patients with acute lung injury, low oxygenation levels have been reported to increase renal RI [ 28].
Inclusion of major nitrite-related hemoglobin species could be important to account for varying concentrations of hemoglobin oxygenation status, especially when implementing to patients with low oxygenation conditions (e.g., ischemia).
Increased RI may be associated with low renal perfusion pressure or low oxygenation levels in patients without AKI but may also be associated with sustained renal injury.
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