Moreover, the probe can be used to image the endogenous nitroreductase in A549 cells under hypoxic condition.
Furthermore, the hepatic progenitor cells induced under hypoxic condition were efficiently differentiated into mature hepatocytes with ALB secretion ability.
They also induced apoptosis selectively at a dose of 10 μM each under hypoxic condition for 5 h.
Under hypoxic condition mimicking that of the infarcted hearts (1% O2), CDCs encapsulated in the hydrogel experienced massive cell death.
One of the major causes is the inferior cell survival under hypoxic condition of the infarcted hearts.
Under hypoxic condition, cardiac differentiation of CDCs was completely silenced in the hydrogel, as confirmed at both mRNA and protein levels.
Interestingly, PFTBA applied through the fibrin hydrogel dramatically enhanced the mRNA of BDNF, NGF, GDNF, N-CAM and VEGF under hypoxic condition.
Under hypoxic condition, compounds 11b, 11c, and 11d increased the intracellular oxygen contents, thereby attenuating the hypoxia-induced accumulation of HIF-1α protein.
In addition we assessed the transcription levels of invasion- Mmp-9 and uPA) and plurinvasion- Mmp-9d genes (Pou5f1, Nanog) invasion- Mmp-9cyst under hypoxic condition.
Notably, the intersection area of channels has high invasive, sprouting and vasculogenesis potential under hypoxic condition, because more HIF1α-positive cells are observed there.
Biochar used in this experiment was produced from rice straw, which was carbonized under hypoxic condition at 600 °C.
