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One of the most interesting findings is the under expression of gelsolin in early regenerative stages.
Here, it is stated that age is correlated with an under expression of proteasomal genes.
In particular, TGFβ can induce the under expression of HNF4α in rat primary hepatocytes and in immortalized murine hepatocytes [ 45].
High-end (over) or low-end (under) expression is indicated by red and blue, respectively, in the heat maps.
On the other hand, the infertile group with Low ROS levels exhibited a under expression in stress response proteins.
Co-directed expression, i.e., identical direction of fold-changes in the two organisms, can be used as an important data filtering criterion: co-directed over expression only, co-directed repression only, both together, both anti-directed directions (under-over and over-under expressions).
GLI1 and GLI2 showed marked under-expression, whereas GLI3 only tended to be under-expressed.
(C) Over- and under-expression of hTERT by gene transfection.
(D) Effects of hTERT over- and under-expression on BMP7-induced breast cancer cell senescence.
(B) Effects of over- and under-expression of hTERT on BMP7-induced breast cancer MCF-7 cell death.
Gene over-expression or under-expression is closely associated with human diseases, which contributes to phenotypic variations and diversity.
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