The under-expression for short travel-times, with (t < 4mbox{ min}) could be a consequence of the characteristic GPS measurement time and does not affect the time scale (langle trangle).
Lung metastasis did not exhibit significant over- or under-expression for these signatures.
However we notice that some of these gene expressions oscillate between over- and under-expression for the last time points.
The expression profile of the eigengene of the Blue module showed a clear under-expression for the lean animals, while it showed overexpression in the obese individuals.
An excess of TNF results in harmful inflammatory responses [ 40], whereas under-expression for TNF has been shown to contribute to pathogen susceptibility [ 41].
Over- or under-expression, for instance, of the signalling components may have disastrous effects on the cellular phenotype, e.g. the development of cancer.
Each gene or miRNA's expression was separately assessed for tissue differences by one-sided Student's t test (under-expression for hypermethylated genes or over-expression for hypomethylated genes).
The DEHP effect is identified by for 2.0-fold over-expression, for 10-fold over-expression, for 2.0-fold under-expression and for 10.0-fold under-expression for at least one dose of DEHP.
Of the 3490 RBBH genes identified, DESeq detected 310 (120 were assigned KO numbers) genes with log2FC over-expression and 364 (188 were assigned KO numbers) with log2FC under-expression for KN in comparison to GC.
A positive bias towards over-expression could be observed for genes related to oxidative stress, kinases, transcription associated proteins and chaperones, and towards under-expression for genes related to proteasome degradation and transporters.
Real-time reverse-transcription PCR (RT-PCR) analyses revealed that levels of gene expression were reduced in the resistant strain compared to the susceptible strain for both candidate genes (2.17-fold and 1.68-fold under-expression for the CAD and the LAP genes, respectively; Figure 2).
