Sentence examples for under evolutionary constraints from inspiring English sources

The rationale for this approach is that interacting residues would necessarily be under evolutionary constraints due to the need to maintain compatibility with the corresponding partner motif and would therefore exhibit increased conservation [26].

Sex chromosomes are considered to be under evolutionary constraints different from those of autosomes.

This lysine is the target of covalent modification by the retinal prosthetic group of these proteins and is under evolutionary constraints.

Third, the SNP was inside a region with strong evolutionary conservation among placental mammals and among vertebrates, suggesting that the region is under evolutionary constraints.

Empirical studies have shown that indels are more easily accommodated within coiled regions of a protein evolving under evolutionary constraints (Benner and Gerloff 1991).

The striking structural similarity underscores that despite low sequence identity, META1 and HslJ have been under evolutionary constraints to retain a similar fold.

For the four remaining cases, an alternative hypothesis could be that the flanking LTRs are under evolutionary constraint or that the NRR regions actually contain uncharacterized repeats that were not detected during similarity searches.

The recent analysis of DNA topography conservation, rather than nucleotide sequence, suggested that up to 12% of the human genome could be under evolutionary constraint [5].

Multiple SNPs in sequences under evolutionary constraint within intron 5 of FHIT defined several related haplotypes with an increased risk of prostate cancer in European-Americans.

Genome-wide analyses of non-coding evolutionary constraint in different taxa support this interpretation: only 5 percent of the basepairs in human non-coding DNA appear to be under evolutionary constraint [6], while approximately 50 percent of the twenty-fold smaller D. melanogaster genome is similarly constrained [7].

Positive scores suggest that a site may be under evolutionary constraint.