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Specific changes observed in these networks under diseased states might serve as biomarkers of disease progression.
Since miRNAs can be detected in the plasma under diseased conditions, circulating miRNAs may function as potential diagnostic markers for cardiovascular diseases [ 55, 76, 77].
Furthermore, insights obtained into the regulation of permeability in the channel offer the promise of devising new strategies for altering the permeability of the channel under diseased conditions.
There are also studies which have investigated Treg expression under diseased conditions in mouse models for T1D [19], [19].
We propose that the "elasticity" of the proteomic regulatory network mediated by balancer proteins may compensate for changes that occur under diseased conditions.
Furthermore, creatinine is removed by hemodialytic strategies [42] but under diseased states uremic compounds of low molecular mass can displace strongly albumin-bound drugs from binding sites responsible for the binding defect of various drugs in uremic sera.
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Oxidative stress can also affect the total mtDNA content in lymphocytes under various diseased conditions [ 28].
Electron microscopes have been proven to be an invaluable tool for examining the ultra-structure of articular cartilage under healthy, diseased, and repair conditions (Table 1).
Disruptions within this principal transcriptome may ultimately drive pathological onset and disease progression, thus elucidation of primary transcriptome dynamics under normal and diseased conditions is required for advanced refinement of disease prediction [ 9, 18].
Under abnormal or diseased conditions, however, chondrocyte metabolism is altered under the influence of the increased influx of pro inflammatory cytokines that activate matrix-degrading enzymes termed matrix metalloproteinases (MMPs) and of reactive mediators that promote cartilage degradation [ 18].
Studies on the potential mutual interactions of BBB transport, the fate of L-DOPA metabolism in the brain, and the number of viable dopaminergic neurons under normal and diseased conditions are needed for improved understanding of Parkinson's disease.
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