The connection between G6PD and MEN observed here suggests that G6PD activity generates a substantial amount of NADPH under conditions of oxidative stress, consistent with previous studies that found G6PD activity to be important under these conditions in other systems (Pandolfi et al. 1995; Ursini et al. 1997; Salvemini et al. 1999; Singh et al. 2007; Legan et al. 2008).
Under conditions of timescale separation consistent with the deterministic QSSA, the noise statistics of the slow species according to the CME of the full network can be approximately described by the following linear FPE (9) ∂P η → s, t ∂t = − ∇ s T J η → s + 1 2 ∇ s T D ss ∇ s P η → s, t.
The level of nuclear expression is higher in cells under conditions of asymmetric self-renewal, consistent with the mRNA expression data, which was described earlier.
Atox1, in turn, may functionally replace GSH under conditions of low total glutathione, consistent with the original functional description of Atox1 as an antioxidant protein.
Experimental results obtained under conditions of glucose excess, were consistent with this scenario and could not be reconciled with the alternative scenario in which temperature dependencies of the k cat values of individual glycolytic enzymes were different.
This implicates a chemical step as rate-limiting under conditions of low O2 concentration, consistent with prior results indicating that kcat was limited by a step that followed aquo release but preceded the HAT.
Our model predicts that partially resistant parasites are more likely to spread in low-transmission areas, but fully resistant parasites are more likely to spread under conditions of high transmission, which is consistent with some epidemiological observations.
Additionally, IGF-I-stimulated phosphorylation of IRS-1 as Ser 636/639 was attenuated under conditions of reduced p110β, a finding consistent with previous work suggesting a dependence on ERK for IRS serine phosphorylation at this site (26).
While this feature of RYE expression alone might suggest that RYE accumulates during sleep to measure sleep recovery and promote waking, the short-sleep phenotype of the mutant and the elevated levels of RYE in various short-sleep mutants and under conditions of sleep deprivation are not consistent with this alternative (so it does seem that RYE is part of the process S).
MH estimators have the advantage of consistent variance even under conditions of sparse data.
