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The reductive elimination of I is assisted by COD to furnish 3 under concomitant regeneration of Ni(COD)2.
The base KOtBu could be replaced with NaOtBu, KOMe, or KHMDS, albeit under concomitant reduction of the yield (entries 6 8, Table 1).
The peak at −114 ppm remained for 60 min and gradually disappeared over 20 h under concomitant emergence of a peak for KF (−213 ppm).
Complex C undergoes a transmetalation with Ni(COD)2 in the presence of a second mole of KOtBu to generate the active catalyst complex D under concomitant release of stable [BPin(OtBu 2]K.
During catalysis sortase A cleaves the conserved Leu-Pro-X-Thr-Gly sorting motif at the Thr residue under concomitant thioester formation at active site Cys184.
Figure 8 Possible scheme of cortical cytoskeleton reorganization resulting in stiffness elevation under concomitant decrease of F-actin content.
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As visible, the BOPP surface is made of nanosized polypropylene fibers that provide the resistant friction force inducing the separation of the graphite nanocrystal edges, thus causing a rolling-up process under the concomitant action of the applied shear stress.
Therefore, we predicted that, under the concomitant regulation of HSP90/Akt and ER stress resulted from proteasome inhibition, GSK3 β might be inhibited (phosphorylated) at an early stage of celastrol treatment and then activated (dephosphorylated) at late stage.
In addition, the study controlled confounding due to risk factors for pancreatitis (e.g., disease under treatment, concomitant medications, and comorbid conditions) by propensity-score matching and multivariate modelling.
Over-expression of RUNX1, CBFA2T3, TCFL5, TNFRSF7 and concomitant under-expression of CD9 characterize cell proliferation and differentiation processes in the hematopoietic lineages.
Over-expression of the EGF7, SEMA6A and CTGF genes with concomitant under-expression of the LSP1 and CD9 genes is characteristic of cell migration and response to wounding.
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