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Fig. 4 Optimal relay policy versus SNR ratio under balancing detection accuracy criterion.
The ama1 gene was chosen as a positive control gene as results from other populations indicate that it is consistently under balancing selection [12] [14].
In addition, the nonMHC markers were highly polymorphic and therefore likely to be in linkage with functional loci under balancing selection [e.g. 68], [69].
Whether or not SRF1 is under balancing selection remains to be seen.
Thus, the population structure of genes under balancing selection should not be pronounced [ 53].
The complement proteins also show a significant enrichment for genes under balancing selection in Africans (Fisher's exact test P = 0.01).
Under balancing selection, some allelic lineages exhibit unusual longevity that predates speciation events, leading to "trans-species polymorphisms" (TSP) used to describe polymorphisms among species [ 49].
Under balancing selection, some MHC alleles or allelic lineages are reported in other species, which indicates that they are ancestral alleles [ 46].
This is contrasting with the pattern of selection observed in vertebrates, in which genes involved in defense mechanisms are under balancing selection in addition to directional selection.
While HDIs are more sensitive towards local adaptation, LDIs may fail to highlight genes that are under balancing selection in only a few populations.
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"It was under-balancing the well and allowing it to flow," Beck said.
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