P1: If an organism mounts a suboptimal (i.e. over- or under-activate) adrenocortical response to a perturbation, it will exhibit inappropriate behaviors for the challenge encountered and fail to return to homeostasis leading to decreased fitness.
A key prediction from this account is that the performance of children with ADHD will be disrupted in settings and tasks with either high (over-arousing) or low (under-activating) rates of stimulus presentation.
Under activating conditions (media with little or no phosphate), the transcriptional activator Pho4, a helix-loop-helix DNA binding protein, enters the nucleus and binds together with the homeodomain factor Pho2 at both upstream activating sequences.
For the genes we assayed, Mediator occupancy was highest at the promoter under activating conditions.
They often bind to the same promoter under activating conditions, and yet their individual contributions to expression of the gene vary widely.
The latter cannot be explained by the assumption that Pho2 binding at N-2 sequences required Pho4 binding at UASp2, because Pho2 could access N-2 sequences under activating conditions in UASp2 mutant cells (Fig. 5).
The nmt1 gene under activating conditions is among the most highly expressed genes in the S. pombe genome [19], [33], and expression levels driven by Purg1 are arguably closer to physiological levels for most genes.
The results are shown in Table 2 for AHD under activating mutations.
(C ) Under activating conditions, decreasing the concentration of CaMKII from 8 µM (red) to 1 µM (blue) results in reduction of the rate of colocalization.
The impact of increased training set size on the average error for AHD under activating mutations is presented as a percentage.
