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Namely, an association involved IgG levels to AMA-1 and IL-10 −1082 under a recessive effect, with higher IgG levels in newborns from IL-10 −1082 AA vs. GG and GA mothers (P = 0.04).
In contrast, maternal IL-13 −1055 was associated with lower IgG levels to AMA-1 under a recessive effect, concerning newborns from IL-13 −1055 TT vs. CC and CT mothers (P = 0.03).
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The excess of homozygotes may possibly represent a recessive effect, as only one homozygote would be expected under HWE, but this excess is not statistically significant 71.
There was a recessive effect of the common G allele of rs16970264 on total and LDL cholesterol (Table S3).
A likelihood ratio test for an additive, a dominant and a recessive effect of the genotyped variants determined that a recessive genetic model was chosen for rs439401, rs405509 and rs769450 (wild type and heterozygous genotype versus homozygous genotype).
Thus, a recessive effect appeared more likely.
When recessive effects occur there may be a large number of variants which can combine to have a recessive effect on risk.
One explanation for this is that an association can be missed due to a recessive effect.
These findings suggest a recessive effect of the T allele on lung cancer risk.
Observing a recessive effect implies that a single wild-type allele is able to compensate for the mutant allele.
A recessive effect is in line with the known function of cystatin C, a potent enzyme inhibitor.
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