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We also studied one novel gene, apolipoprotein B mRNA editing enzyme (APOBEC2), which is located directly under a linkage peak (lod score of 4.44) for total cholesterol in our linkage study of 5775 individuals from twin families from the GenomEUtwin (www.genomeutwin.org).org
Similarly, Richard Spritz (University of Colorado Denver, USA) presented an approach that integrates GWAS with the sequencing of siblings under a linkage peak.
To account for a possible substructure in the self-identified ethnic groups, we inferred ancestry in the Dallas Heart Study participants with STRUCTURE 23 under a linkage model with 2270 ancestry-informative SNPs 24 as described.
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Under this option, a linkage project may be configured to be on-going.
Following the study design outlined in the Introduction, in the first stage of our analysis we separately tested for MS association five microsatellites under an MS linkage peak in the 17q11.2 region of DNA (for details see Genomic region and marker selection, data preparation and genotyping and Supplementary Table S1).
This document identified the target as "Belgrade Warehouse 1," but under a heading called "linkage" called it the "HQ for the Federal Directorate Supply and Procurement".
Interestingly, two of the genes in this network have previously been associated with schizophrenia as deregulated in postmortem brains (CCND2 [39]) or positioned under a highly significant linkage peak (PTPN1[40]).
We therefore selected nine large Icelandic non- BRCA1/2 families for a GWS of high-risk genes under a parametric dominant linkage model.
Finally, the results of a fine-mapping strategy investigating candidate genes mapping under a peak of linkage in US RA families has identified another RA susceptibility locus mapping to the STAT4 gene in US subjects, which has been subsequently confirmed in Swedish and Korean populations (11, 12).
Non-differential under-linkage or under-reporting could lead to underestimation of vaccine effectiveness.
The assignment of an isolate to a particular population was done under the linkage model.
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