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However, without changing sFlt-1 levels below baseline lowering lipids or other yet undefined factors appear to be of more relevance than reducing sFlt-1.
Many of these undefined factors may eventually be characterized as having roles in lipid droplet formation.
Although the culture method shown above can bypass the use of Matrigel, because it requires medium derived from MEFs, the method still relies on multiple undefined factors.
Taken together, our findings suggested that the defined culture conditions described herein are suitable for culturing hiPSCs with the added benefit of eliminating contamination risks caused by undefined factors.
However, their experiments were performed on Matrigel and in medium containing serum and thus included undefined factors that could have interfered with the primitive endoderm-inducing effect of BMP4.
Undefined factors trigger the aggregation of WT-SNCA within neurites and the cytoplasm of degenerating neurons to form so-called Lewy bodies and Lewy neurites which are microscopically visible in nearly all variants of PD, provoking the concept that SNCA oligomerization plays a key role in the neurodegenerative cascade [5].
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The data suggest that M28 strains may lack a still undefined factor required, in addition to the pili, for biofilm formation.
In line with this notion, VCC degradation by PrtV was inhibited by yet undefined factor(s) in the more complex bacterial culture media.
It was also reported that an undefined factor which leads to DIC was transported to the baby by the placenta and caused thrombocytopenia in the newborn [ 14].
Although detailed information concerning its composition is restricted, KSR does not contain any undefined growth factors or factors that promote differentiation [37].
Transcriptional differentiation is correlated with combinations of known and previously undefined transcription factors, suggesting that the process is tightly regulated.
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