Here, we integrate structural, biophysical, and modeling approaches to identify the hitherto unknown substrate-binding site in TRiC and uncover the basis of substrate recognition.
Both questions have broad reaching impact on human health, including the development of novel strategies to combat age-induced cellular damage and uncovering the basis of genome partitioning defects associated with maternal age. A. Gametogenesis resets lifespan by eliminating age-induced cellular damage in S. cerevisiae.
To uncover the basis of the age- and strain-dependent susceptibility to DXR-induced apoptosis, we assessed oocyte DNA repair.
Certainly, the availability of the conditional in vivo model described herein will allow the field to uncover the basis of the sensitivity of developing neurons to TDP-43 misregulation.
Nevertheless, investigating any differences in students' actual engagement with the external representations during the group exercise that may arise from the representational differences is a natural next step to uncover the basis for the qualitative differences observed in this study.
To uncover the basis for this, we investigated the spectral properties of the Y120A/P121A HCCS double mutant, both in the presence and absence of the cytochrome c acceptor substrate.
To uncover the basis for various substrate-protein recognition by chaperonin GroEL, few studies have been carried out in the past involving several in vivo and in vitro substrates [ 10].
In particular, the current study focused on uncovering the basis for C. sordellii's preference for infecting both soft tissues and the vagina, while not infecting the gastrointestinal tract (a major clinical difference between C. difficile and C. sordellii).
In plants, growth development, cell patterning, yield, and biomass accumulation are controlled by functional genetic networks of several orders of magnitude that will require various complementary research approaches to uncover the basis of this functional genetic complexity.
