A review in 2014 by the three local clinical commissioning groups uncovered problems including poor staff morale, weak recruitment and retention, flawed procedures and patchy communications with GPs.
It is because of this uncovered gap problem that we define a gene with ≥50% of the length covered by at least one read to be sufficiently expressed.
In fact, we found that this uncovered gap problem was even more serious in many published prokaryotic datasets we have reanalyzed, a typical example from [ 60] is shown in Additional file 1: Figure S4.
To deal with the uncovered gap problem, we used a sliding window to compute the centroid coverage of each position on a strand of DNA, assuming that if the flanking regions of a position are transcribed, it is very likely that the position itself also is transcribed.
In particular, TruHMM overcomes the aforementioned limitations of the earlier method by allowing a transcript to have highly non-uniform coverage at different positions, and explicitly addressing the uncovered gap problem using a sliding window-based centroid read counting strategy in a pre-processing step.
Researchers reviewing the breast cancer trials said their investigation uncovered numerous problems, starting with Dr. Bezwoda's misrepresentation of the drugs he used in the trials.
Hewlett-Packard has said that its internal investigation, set off by a whistle-blower, uncovered major problems at Autonomy that were present before the merger.
Carmen Segarra, a bank examiner with the Fed, uncovered numerous problems at Goldman Sachs, but was ordered by her supervisor to change her report.
To assemble all types of full length transcripts using the directional RNA-seq shoreadsads, we have developed a new Hidden Markov Model based algorithm, TruHMM (TRancription Unit assembly by a Hidden Markov Model), attempting to addresses the highly non-uniform read coverage and uncovered gap problems of current RNA-seq techniques.
More than nine months later, an F.D.A. inspector appeared at Dr. Linden's research center and uncovered myriad other problems.
