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High-throughput screens have uncovered interactions between antibiotics and have lead to the surprising insight that, although certain combinations are less efficient, they may hinder the evolution of multidrug resistance in the long term (Yeh et al. 2009).
Linkage analysis in a segregating population and gene expression analysis of the CsGL1 and CsGL3 genes in csgl1, csgl3, and csgl1 + 3 genetic backgrounds uncovered interactions between the two genes.
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We believe that this study may pave the way for further characterization of the function played by these two genes during reproduction and uncover interactions unknown at the present time.
The GarsC201R mouse is a valuable new resource both for studying the pathogenesis of defects in this enzyme and for use as a genetic tool to uncover interactions with cellular pathways affecting motor and/or sensory neuronal function.
Such approaches may uncover interactions between signal transduction routes, which are to be verified in vivo.
Since the yeast collection of deletion mutants has become available, genome-scale assays to uncover interactions between non-essential genes, for example by Synthetic Genetic Array (SGA) technology, have become routine in molecular genetics [ 2].
In addition to showing that epistasis contributes to variation in human traits, the work of Brown et al. could help to uncover interactions behind complex traits beyond the expression level of a gene that could not previously be investigated.
An advantage of the RF approach is that the final decision tree models may uncover interactions among genes and/or environmental factors that do not exhibit strong marginal effects (Cook et al., 2004), especially when combined with methods such as ReliefF (see Section 2.6) for choosing the attributes to be used as nodes.
Information generated via microarrays might uncover interactions between the mammary gland and Streptococcus uberis (S. uberis ) that could help identify control measures for the prevention and spread of S. uberis mastitis, as well as improve overall animal health and welfare, and decrease economic losses to dairy farmers.
For example, classical genetic interactions uncovered strong negative interactions with Rqh1 and Sgs1, which are orthologous DNA helicases of the RecQ family.
We also uncovered unexpected interactions between YAP1 overexpression and xylose metabolism.
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