To our knowledge, this is the first study to define the structural dynamic consequences of the selective impairment of an NBS and to uncover divergence in the conformational cycles within the ABC exporter superfamily.
The phylogenetic and biochemical analyses have uncovered functional divergence between SAP30 and SAP30L in the domain that associates with the nuclear matrix.
Comparative transcriptional profiling of adult interspecific hybrids and their parental species has uncovered widespread divergence of the mechanisms controlling gene regulation, revealing incompatibilities that are masked in comparisons between the pure species.
However, our experiments uncovered remarkable divergences between single NE components concerning their individual polarization.
Comparison of translation efficiencies for orthologous genes should uncover regulation divergence, and thus the differential functional importance of those genes in diverged species [ 14, 15].
Furthermore, our genome-scale, in silico retroposon analysis based on published genome data uncovered a complex divergence history among pelican, heron, and ibis lineages, presumably involving ancient interspecies hybridization between the heron and ibis lineages.
In addition to the shifting availability of copepod habitat associated with sea level changes, the outcrops themselves are not stable over the longer time periods that would be required with standard mtDNA molecular clocks to produce the CYTB divergences uncovered among T. californicus populations.
The analysis of the phylogeny and the detailed protein interaction profiles uncovered a likely functional divergence between FEZ1 and FEZ2, since FEZ2 acquired in respect to FEZ1/UNC-76 additionew new interactors and is ubiquitously expressed and not restricted to neuronal cells, as is FEZ1/UNC-76.
The use of variation data, in addition to sequence divergence information, uncovered previously undetected positive selection signatures in neural genes.
Specifically, outlier loci/regions of divergence were uncovered on every chromosome, indicating that directional selection is acting across the entire genome, rather than being restricted to a few chromosomes, as was the case for the Atlantic cod [ 28].
However, even though we uncovered a number of divergence events between closely related lice in different microhabitats, these are still relatively rare across avian feather lice, because in most cases, lice in the same genus possess the same microhabitat specialization.
