The large number of RNA editing sites in our study gave us an opportunity to uncover characteristics of the editing targets.
Finally, we determined a set of 'CNS-signature' genes that uncover characteristics of several common neuronal processes in the CNS, with marked over-representation of specific features of synaptic transmission, ion transport and cell communication, as well as numerous novel unclassified genes.
These techniques were used in the study of normal subjects to understand brain functioning and in pathological subjects to uncover characteristic pattern useful for diagnosis [41 43].
Figures 1 and 2 show how α profiles are used to uncover characteristic scales in human DNA sequences.
Studies of model organisms with young sex chromosomes have uncovered molecular characteristics at the initial stages of differentiation that align with theoretical expectations [ 5, 15, 17].
Recent epigenomic profiling of hESCs has uncovered several characteristics that, although not absolutely unique to hESCs, appear particularly pervasive in these cells [ 52- 54].
We examined the membrane potential (Vmem) changes exhibited by human mesenchymal stem cells (hMSCs) undergoing adipogenic (AD) and osteogenic (OS) differentiation, and uncovered a characteristic hyperpolarization of differentiated cells versus undifferentiated cells.
Studies by Cobb et al. in a murine model uncovered a characteristic set of miRNAs, which are enriched in Treg with respect to naïve CD4 T cells; these include miR-223, miR-146, miR-155, miR-21, and miR-24 [ 17].
Such genome-wide analysis of bona fide NHR binding sites provides sufficient numbers to achieve statistical power to uncover core characteristics of specific transcription factor-DNA interaction by examining the population characteristics of the DNA binding sites in a genome-wide scale.
We also uncover new characteristics for the crater geometry, on the dimensions and form of the central uplift, circular fault systems and three-dimensional mass distribution of formations.
