Sentence examples for uncovered alterations from inspiring English sources

Analysis of motor abilities in the Mbd5 +/GT mice uncovered alterations in strength, balance, and movement coordination.

Current Research and Scholarly InterestsOur laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers.

These subtypes uncovered specific alterations in DNA methylation and transcription as well as in signaling pathways involved in tumor-stromal cross-talk.

Using a combination of computational and experimental genomics approaches, his lab has uncovered novel alterations in genes within receptor tyrosine kinase-regulated pathways and in genes regulating RNA splicing and chromatin remodeling.

For example, mutational analysis of the tyrosine phosphatase (PTP) gene superfamily uncovered genetic alterations in about 26% of colorectal tumors.

Overall, deep-coverage sequence analysis techniques uncovered VHL alterations within the neoplastic fraction of these tumors at higher frequencies than previously reported.

Although significant progress has been made to uncover genetic alterations in HCCs, our understanding of genetics involved in the initiation and progression of HCC is far from complete.

Independent research groups have attempted to uncover pertinent alterations in these factors and how they correlate with cancer state [ 25– 27].

Most of the current driver identification approaches aim to uncover somatic alterations, point mutations in particular, that occur at a statistically significant rate in cancer.

GSEA is a robust computational tool that can uncover subtle alterations in complex diseases by utilizing expression data to characterize gene signatures within pathways.

We applied a stepwise methodology to uncover genomic alterations that are informative of observed patterns of pathway activity changes in glioblastoma multiforme, providing a high-level picture of the cell's molecular phenotype.