Sentence examples for uncovered a role of from inspiring English sources

By targeted metabolomics and isotope tracing experiments in loss- and gain-of-function cell and mouse models of Slc22a1, we uncovered a role of SLC22A1 in the efflux of acylcarnitines from the liver to the circulation.

In this study, we uncovered a role of LRRK2 in modulating the innate immune response in macrophages.

The same study then also uncovered a role of Sir2 for the efficient retention of aggregates by mother cells and the clearance of daughter cells from aggregates via polarisome-dependent retrograde transport along actin cables.

Second, we uncovered a role of the PI3K-Akt pathway in hSKPs.

We have also uncovered a role of X-linked inhibitor of apoptosis protein in the regulation of endogenous Par-4 levels through inhibition of caspase-mediated cleavage.

Our findings revealed the essential roles of GATA2 in EHT and granulocyte development through regulating SPI1, and uncovered a role of Notch signaling in granulocyte generation during hematopoiesis modeled by human ESCs.

Mechanistic studies further uncovered a role for SUMOylation of the PAF1 complex component, parafibromin (CDC73), in potentiating antiviral gene expression.

Our data uncover a role of keratins, which to our knowledge is previously unreported, in the maintenance of HDs upstream of plectin, with implications for epidermal homeostasis and pathogenesis.

Together, our results uncover a role of LRRK2 in modulating innate immunity by enhancing the signaling strength of the Nod2-Rip2 pathway.

By uncovering a role of the src-substrate cortactin in AChR clustering this study suggests a previously unappreciated way by which src could regulate AChR aggregation at the NMJ.

However, these screens failed to uncover a role of DUBs in the regulation of Notch signaling, probably attributable to the fact that many DUBs exhibit pleiotropic effects in early development.