In contrast to this canonical role, our earlier in vitro studies on the PHD1 domain have uncovered a function of the PHD1 domain in the allosteric regulation of the demethylase activity of KDM5A40.
Our attempts to uncover a function for TNFα-induced p110δ in ECs or synovial fibroblasts were not successful, as p110δ inhibition did not affect survival, migration or production of IL-6 or IL-8 in TNFα-stimulated HUVECs, or production of IL-6, IL-8 or CCL2 [chemokine (C-C motif) ligand 2] in TNFα-stimulated synovial fibroblasts (results not shown).
In addition, we uncovered a novel function of RSK in anterograde axonal transport.
Our group uncovered a novel function for menin in the stress response in Drosophila.
In conclusion, our study has uncovered a potential function for PC-1 in the endothelial compartment in the developing kidney, which is likely important for proper glomerulogenesis.
We have uncovered a novel function of FancJ in centrosome biogenesis and established centrosome amplification as an integral part of the ICL response.
Using this approach together with Bmi-1-KO mice, we uncovered a novel function of the Bmi-1/p16Ink4a Bmi-1/p16Ink4a regulation of SMG function.
Using real-time in vivo imaging of p16Ink4a expression in Bmi-1-KO mice, we uncovered a novel function of the Bmi-1/p16Ink4a Bmi-1/p16Ink4atrolling homeostasis of the submandibular glands (SMGs), which secrete saliva into the oral cavity.
Recent work uncovered a key function for alternative splicing in the regulation of neuronal recognition events.
This approach, in conjunction with analysis of Bmi-1-KO mice and aged wild-type (WT) mice, uncovered a novel function of the Bmi-1/p16Ink4a Bmi-1/p16Ink4aliferation control of stem or pathwaytor cells in the submandibular glands (SMGs), which secrete saliva into the oral cavity (Young & van Lenneproliferation
We do not think that this result uncovers a function for the genes in directly activating expression.
