Exact(2)
This use of genetic interactions as a tool to uncover function improved again with the use of more quantitative data, such as that obtained with the use of dSLAM (diploid synthetic lethality analysis with microarrays [10]), GIM (genetic interaction mapping [11]) and SGA (synthetic genetic array [12]) techniques.
Box 2. Caveats of overexpressing MMPs to uncover function As discussed in the text, functions for some MMPs, such as MMP-1 and MMP-9, in fibrosis have been suggested from studies that involved overexpression – typically by viral transduction – of the enzyme.
Similar(58)
A few minutes of exploration can uncover functions that make Facebook not just an addiction but a pleasure to use.
Analyses of the gene pairs spanning a putative bidirectional promoter may also help uncover functions for the vast array of unknown genes that remain to be characterised [ 53].
Thus, investigating the function of evolutionarily conserved proteins related to human phenotypes that remain cryptic in cnidarians should help uncover functions presumably coopted for different tasks in bilaterians and cnidarians.
First, we have hypermorphic alleles for both genes; these could uncover functions of the proteins that might otherwise be masked by redundancy, but mutant fish are viable and fertile, and no additional phenotype could be detected.
Additionally, SEQRS data can be integrated with functional genomics data to uncover biological function.
Although immunolocalization data support a role for CNNM4 in retinal function and biomineralization, further work will be required to uncover its function in these tissues.
Here, I discuss how RNAi screening can be used effectively to uncover gene function.
In this study, we employed S89G-DMP1 micentomice to uncover the function of DMP1-PG during astrocytes maturation and maintenance of BBB integrity.
These alleles offer the ability to non-invasively control activity of diverse cell types to uncover their function and dysfunction at any developmental stage.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com