For example, we uncovered feedback loops amplifying PI3K signalling, in line with the known trastuzumab resistance of this cell line.
Several studies have investigated the potential importance of PI3K inhibition as a therapeutic strategy in HER2-amplified breast cancer, but these studies have uncovered feedback loops and other factors that may limit the use of PI3K inhibitors as single agents.
Knowing this means that I had to find ways to tap into this silent customer base to uncover more feedback and get a full picture of their experiences.
This suggests that these Ribi genes might have an unknown regulatory role, or the association may uncover a feedback loop where other genes are over-expressed to compensate for the loss of other Ribi genes.
In addition, we uncovered two feedback loops of Egr2.
We uncover a positive feedback loop in which STC1 promotes the release of ATP from cells in vitro and in vivo.
Consecutive statistical analyses of blood samples over a period of 12 months were used to assess performance, provide feedback and uncover incidences of hypoglycaemia.
Thus, we uncover an important negative feedback regulatory loop that controls pro-inflammatory signalling in endothelial cells that may impact vascular inflammatory diseases.
More unexpected is the negative feedback uncovered here between FGF2 and HIF-1α during early hypoxia: Fig. 5B and 5C clearly show that HIF-1α siRNA up-regulates FGF2 protein whereas FGF2 siRNA up-regulates HIF-1α after 3 h of hypoxia.
Accordingly, a recent report has uncovered a positive feedback between IGF2 and its intragenic mir-483, where the mature miR-483-5p miR-483-5p miR-483-5p 5'UTR of IGF2 moleculeomoting IGF2 transcription bindscilitotheg the association of the helicase DHX9 (24).
