Sentence examples for uncontrolled target from inspiring English sources

Both hypotheses involve an increase of TCF7L2 transcriptional activation, leading to uncontrolled target gene expression.

The inappropriate activation of the Wnt signaling pathway and the subsequent formation of nuclear LEF/TCF/ β-catenin complexes lead to uncontrolled downstream target gene activation and ultimately result in the malignant transformation of cells [ 10].

Thus, one signaling cycle or constant action of NF-κB from LMB or CHX, respectively, induced opposite functional consequences: premature termination or uncontrolled accumulation of target gene transcripts.

Its oncogenic effect is mediated by uncontrolled activation of target genes that for example, enhance cell proliferation, such as c-myc and cyclin D1.

However, the clinical use of cytotoxic cancer drugs, which target uncontrolled, dividing cancer cells, is limited by the severe side effects caused by killing fast dividing normal cells, such as blood cells.

Subsequently, it binds to transcription factors and drives the uncontrolled expression of target genes implicated in cell proliferation, transformation, and tumor progression, such as Myc, matrix metalloproteinase 7, Axin-2, the cell adhesion molecule L1-CAM, the metastasis gene S100A4, and others [ 33, 43, 44].

The discovery of antiretroviral medication that suppresses inflammation in addition to HIV replication or adjunctive therapy targeting uncontrolled inflammation may be important in the prevention of comorbid conditions associated with chronic HIV infection, such as diabetes.

Over the last few decades, EGFR has been investigated as a major target for uncontrolled tumor growth in various types of cancers.

This uncontrolled before-after study (TargET-Knee-Pain) aims to test the principle that exercises targeted at the specific physical impairments of older adults with knee pain may be able to significantly improve those impairments.

It is reasonable to assume that, for C-type molecules, it is generally acceptable to escape from the redox control, as long as they dimerize with an inhibitor, or if the new heterodimer cannot recognise and bind to promoters of downstream targets that need to be controlled by the redox mechanism – thus preventing uncontrolled activation of downstream targets.

IO are often well tolerated; however, uncontrolled and unexpected off-target effects can occur, resulting in wide-ranging and varied toxicities.