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In one clinical trial, ARC1905 is used for neovascular AMD in combination therapy with either multiple doses or with only one induction dose of intravitreal ranibizumab in a non-randomized, open-label, uncontrolled, safety study (ClinicalTrials.gov Identifier: NCT00709527).
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For decades, traffic engineers have resisted using markings at uncontrolled crosswalks due to safety and liability concerns.
This paper presents a method to assess the safety of uncontrolled intersections considering two major properties of traffic conflicts conflict probability and severity.
Supervisory control theory deals with automatic synthesis of supervisory controllers that ensure safe behavior of the supervised system, based on the models of the uncontrolled system and the (safety) control requirements.
This safety issue for uncontrolled intersection has been addressed by Lu et al. (2014).
This uncontrolled development poses sanitation and safety risks to residents in these areas.
This was a multicentre, open-label, uncontrolled study to assess the safety and efficacy of subcutaneously administered epoetin delta over 1 year.
This subsequent, 26-week, open-label, uncontrolled assessment period evaluated the safety and efficacy of (i) continued exenatide once-weekly treatment and (ii) switching from sitagliptin or pioglitazone to exenatide once-weekly.
Initial uncontrolled clinical observations confirm the safety and potential effectiveness of memantine in reducing binge-eating with less effect on weight (Brennan et al. 2008; Hermanussen and Tresguerres 2005).
In total, 50 infants were enrolled to this open, uncontrolled study, which evaluated the safety and immunogenicity of an aluminium adjuvanted 11-valent mixed-carrier diphtheria toxoid or tetanus protein-conjugated vaccine (11-PncTD) when administered in three doses at 6, 10 and 14 weeks of age simultaneously with DTwP//PRP-T and OPV vaccines in Filipino infants.
To date, several SIMS are available, but few and uncontrolled comparative data have assessed their safety and feasibility.
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CEO of Professional Science Editing for Scientists @ prosciediting.com